Experimental Lung Inflammation Receptor Knockout Mice Prevents Invariant NKT Cell Defects in Vitamin D
نویسندگان
چکیده
منابع مشابه
Vitamin D receptor-deficient mice fail to develop experimental allergic asthma.
The active metabolite of vitamin D (1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3))) is known to modulate the immune response in Th1 cell-directed diseases. To investigate the role of vitamin D in Th2 cell-directed diseases, experimental allergic asthma was induced in vitamin D receptor (VDR) knockout and in wild-type (WT) mice. As expected, WT mice developed symptoms of airway inflammation with a...
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